30th Annual Open Scientific Virtual Meeting
August 7-8, 2020
Symposia and "Podium" Presentations

Podium and Poster presentations will be available to view at anytime
August 1, 2020-August 8, 2020
Symposiums will open and close at the scheduled time.
Presenting authors will be in attendance at the "Questions and Answers" Sessions indicated.

FRIDAY AUGUST 7, 2020

MSIS appreciates Support from our Exhibitors

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the American Academy of Orthopaedic Surgeons and the Musculoskeletal Infection Society. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians. The American Academy of Orthopaedic Surgeons designates this Other activity, MSIS 30th Annual Open Scientific Virtual Meeting, for a maximum of 6.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For all Symposia, and Question and Answer sessions, please E-mail your question(s) for the authors to msismeeting.2020@gmail.com. Please Identify the Presentation/Poster by # and Title as listed and include your name.

SYMPOSIUM #1

6:00pm-7:00pm Central Time

New Approaches to the Diagnosis and Management of Periprosthetic Joint Infection (PJI) of the Shoulder
Moderator: Eric Ricchetti, MD

Eric Ricchetti, MD
Orthopaedic Surgeon
Cleveland Clinic
Cleveland, OH

Grant Garrigues, MD
Orthopaedic Surgeon
Midwest Orthopaedics at Rush
Chicago, IL

Jason Hsu, MD
Orthopaedic Surgeon
University of Washington
Seattle, WA

Surena Namdari, MD
Orthopaedic Surgeon
Thomas Jefferson University/Rothman Institute
Philadelphia, PA

SESSION I

7:15pm-8:20pm Central Time

Introduction, Carlos Higuera Rueda, MD
SYMPOSIUM 1 "Questions and Answers"
Moderator: Moderator: Eric Ricchetti, MD
CLINICAL RESEARCH I "Questions and Answers"
Moderators: Antonia F. Chen, MD/MBA; Barry Brause, MD

6: The routine use of synovial alpha-defensin is not necessary
Derek Amanatullah, Robin Cheng, James Huddleston, William Maloney, Andrea Finaly, Shanthi Kappagoda, Gina Suh, Stuart Goodman

10: The Surgical Treatment of Deep Infection in the Native Shoulder Joint
Tyler Henry, Michael Gutman, Amy Backal, Surena Namdari

19: Early versus late rotational gastrocnemius reconstruction for total knee arthroplasty infections
Herrick Siegel, Mattthew Hess, Jason Gay, Jeffrey Pearson

21: Stage 2 reimplantation for prior infected hip and knee arthroplasties with normal CRP and elevated ESR
Herrick Siegel, Kevin Wall , Matthew Hess, Jason Gay

23: Are Intraoperative Cultures Necessary if the Aspiration Culture is Positive? A Concordance Study in Periprosthetic Joint Infection
Alberto Carli, K. Keely Boyle, Milan Kapadia, Michael Henry, Andy Miller

24: Periprosthetic Joint Infection after Primary TKA in the Medicare Population: How Frequently are Patients Revised at a Different Hospital?
K. Keely Boyle, David Landy, Brian Chalmers, Andy Miller, Michael Cross, Milan Kapadia

25: Direct Anterior Approach to the Hip Does not Increase the Risk for Subsequent Periprosthetic Joint Infection
Noam Shohat, Karan Goswami, Timothy Tan, Leigham Breckenridge, D'Andrew Gursay, Samuel Clarkson, Javad Parvizi

27: Elevated Fructosamine Levels are Associated with Increased Risk for Periprosthetic Joint Infection Following Total Hip Arthroplasty: A Prospective Multi-center Study
Noam Shohat, Karan Goswami, D'Andrew Gursay, Leigham Breckenridge, Ran Schwarzkopf, Javad Parvizi

29: Laminar Air Flow Does Not Have a Protective Effect on the Rate of Periprosthetic Joint Infection After Primary Total Joint Arthroplasty
Samuel Clarkson, Qiaojie Wang, Chi Xu, Timothy Tan, Samuel Clarkson, Karan Goswami, Javad Parvizi

30: Predictive modeling with Next generation sequencing: a Validated Multi-Institutional Adjunct for Diagnosis of Periprosthetic Joint Infection
Samuel Clarkson, Karam Goswami, Orthopaedic Genomics Workgroup, Javad Parvizi

31: Reinfection or Persistence of Periprosthetic Joint Infection? Next generation sequencing Reveals New Findings
Samuel Clarkson, Karan Goswami, Orthopaedic Genomics Workgroup, Javad Parvizi

32: Who Will Fail Following Irrigation and Debridement for Periprosthetic Joint Infection: A Machine Learning Based Validated Tool
Noam Shohat, Karan Goswami, Timothy Tan, Michael Yayac, Alex Soriano, Ricardo Sousa, Marjan Wouthuyzen-Bakker, Javad Parvizi

34: Hepatitis C Patients have Higher Risk of Revisions after TJA
Emanuele Chisari, Christopher Gardner, Javad Parvizi

36: Inflammatory Bowel Diseases Increases the Risk of Periprosthetic Joint Infection
Emanuele Chisari, Darran D’Mello, Javad Parvizi

37: Organism Profile Causing Periprosthetic Joint Infection: The List is Growing
Santiago Restrepo, Hannah Groff, Karan Goswami, Emanuele Chisari, Javad Parvizi

40: Calprotectin Lateral Flow Test: A Potential Rule Out Test for Periprosthetic Joint Infection
Carlos Higuera Rueda, Jared Warren, Hiba Anis, Kathy Bowers, Tejbir Pannu, Jesus Villa, Alison Klika, Jessica Colon-Franco, Nicolas Piuzzi

46: Rotational gluteus maximus flap with reimplantion of hip arthroplasty in patients that have prior resection arthroplasty
Herrick Siegel, Mattherw Hess, Christopher Odom, Kevin Wall

47: Resection Arthroplasty for Periprosthetic Joint Infection Following Total Hip or Knee Arthroplasty is Associated with High Attrition Rate and Mortality
Jesse Otero, Cameron Barton, David Wang, Qiang An, Timothy Brown, John Callaghan

51: Extended Oral Antibiotics Prevent PJI in High-Risk Cases: 3,862 Patients with 1-Year Follow-Up
Michael Kheir, Julian Dilley, Mary Ziemba-Davis, R. Michael Meneghini

73: Diagnostic Value of D-Dimer for Periprosthetic Shoulder Infection
Benjamin Zmistowski, Thema Nicholson, Surena Namdari

MSIS BUSINESS MEETING

8:30pm-9:00pm Central Time

MSIS Members Only

SATURDAY AUG. 8, 2020

MSIS appreciates Support from our Exhibitors

SYMPOSIUM #2

9:00am-10:00am Central Time

Exploring the Unique Benefits of Using Bacteriophages to Treat MSK Infections, from the Bench to the Bedside.
Moderator: Hesham Abdelbary

Hesham Abdelbary, MD
Orthopaedic Surgeon
University of Ottawa
Ottawa, Canada

Cynthia Barbosa da Silveira, PhD
Biologist
University of Miami
Miami, FL

Gina Suh, MD
Infectious Disease Physician
Mayo Clinic
Rochester, MN

Eddie Schwarz, PhD
Scientist
University of Rochester Medical Center
Rochester, NY

SESSION II

10:15am-11:05am Central Time

Introduction, Carlos Higuera Rueda, MD
SYMPOSIUM II "Questions and Answers"
Moderator: Hesham Abdelbary MD
BASIC SCIENCE "Questions and Answers"
Moderators: Alex C. McLaren, MD; Laura Certain MD

5: A Novel Activated-Zinc Antiseptic Solution Effective Against Staphylococcus aureus and Pseudomonas aeruginosa in a Pig Model
Derek Hill, Cody Pinger, Erica Noland, Kevin Morton, Alessandra Agostinho Hunt, Elizabeth Pensler, Sarah Cantu, Paul Attar, Ahmed Siddiqi

7: Staphylococcus aureus initially and preferentially utilizes biofilm mediated tolerance prior to antibiotic resistance
Derek Amanatullah, Robert Manasherob, Jake Mooney, David Lowenberg, Paul Bollyky

8: Staphylococcus epidermidis Biofilms Have a High Tolerance to Antibiotics in Periprosthetic Joint Infection
John Koch, Taylor Pust, Alex Cappellini, Jonathan Mandell, Dongzhu Ma, Neel Shah, Kimberly Brothers, Kenneth Urish

11: The Staphylococcus aureus Toxin-Antitoxin system YefM-YoeB is associated with extracellular dependent antibiotic tolerance and biofilm formation
Kimberly Brothers, Dongzhu Ma, Kenneth Urish

12: Sub-MIC vancomycin promotes Staphylococcus aureus biofilm formation, infection, and pathogenesis.
Kenneth Urish, MasashiTaguchi, Kimberly Brothers, Lance Thurlow, Dongzhu Ma

15: Differences between Acute and Chronic Periprosthetic Joint Infection in a Mouse Model; Transition from an acute to chronic infection start at an early time period.
Masashi Taguchi, Shinsuke Kihara, Peter Mittwede, Kimberly Brothers, Freddie Fu, Kenneth Urish

17: Direct antimicrobial activity of WLBU2 against S. aureus biofilms is enhanced in physiologic buffered saline
Jonathan Mandell, Berthony Deslouches, John Koch, Kenneth Urish

18: A distinctive release profile of vancomycin and tobramycin from a new and injectable polymeric dicalcium phosphate dehydrate cement (P-DCPD)
Emily Ren, Weiping Ren, Rahul Vaidya, Paul Begeman, Angelica Guardia, Shi Tong

26: Efficacy of Various Surgical Irrigation Solutions Against Established Biofilm: A Comparative in vitro Investigation
Jeongeun Cho, Karan Goswami, Kamolsak Sukhonthamarn, Javad Parvizi, William Arnold

33: Inhibition of Angiotensin Converting Enzyme Impairs Anti-Staphylococcal Immune Function in a Preclinical Model of Implant Infection
Rishi Trikha, Danielle Greig, Benjamin Kelley, Zeinab Mamouei, Troy Sekimura, Nicolas Cevallos, Nicholas Bernthal

49: Local Antibiotic Delivery via Calcium Sulfate for Orthopaedic Infections
Daniel Driscoll, Kathleen Turajane, Ajay Premkumar, Xu Yang, Andy Miller, Mathias Bostrom, David Wellman, Ashley Levack, Alberto Carli

50: Thermal Stability and In Vitro Elution Kinetics of Alternative Antibiotics when used in Polymethylmethacrylate (PMMA) Bone Cement
Alberto Carli, Kathleen Turajane, Xu Yang, Andy Miller, Mathias Bostrom, David Wellman, Ashley Levack

77: Polymicrobial Synergy: Staphylococcus aureus - Candida albicans Coinfection Increases Colonization and Antibiotic Resistance
Zeinab Mamouei, Benjamin Kelley, Nicolas Cevallos, Ameen Chaudry, Nicholas Bernthal

78: In Vitro Analysis of Anti-Biofilm Effect of Intraoperative Irrigation Solutions
Ajay Premkumar, Sita Nishtala, Mathias Bostrom, Alberto Carli

92: Spatial distributions of cytokines in chronic localized infections
Taylor Shackleford, Nicole Prince, Jonathan Boyd, Julia Penatzer, Matthew Dietz

111: Minimum Biofilm Eradication Concentration of Caspofungin against Candida and Aspergillus
Jessica Burns, Rex Moore, Paulo Castaneda, Derek Overstreet, Alex McLaren

11:05am-11:30am Central Time BREAK

SYMPOSIUM #3

MSIS appreciates Support from our Exhibitors

11:30am-12:30pm Central Time

Extended Use of Antibiotics for Prophylasis and Treatment after Orthopaedic Surgery
Moderator: Thorsten Seyler, MD

Gregory Della Rocca, MD, PhD
Associate Professor
University of Missouri School of Medicine
Columbia, MO

Jessica Seidelman, MD
Infectious Disease Physician
Duke University School of Medicine
Durham, NC

Thorsten Seyler, MD, PhD
Orthopaedic Surgeon
Duke University School of Medicine
Durham, NC

SESSION III

12:45pm-1:50pm Central Time

Introduction, Carlos Higuera Rueda, MD
SYMPOSIUM III "Questions and Answers"
Moderator: Thorsten Seyler, MD
CLINICAL RESEARCH II "Questions and Answers"
Moderator: Brian Klatt, MD; Gina Suh, MD

53: The CRIME80 Predicts Failure of Debridement, Antibiotics, and Implant Retention (DAIR) for Total Hip and Knee Arthroplasty Acute Hematogenous Periprosthetic Joint Infection
Brian Chalmers, Milan Kapadia, Y-fen Chiu, Andy Miller, Michael Henry, Alberto Carli

54: The KLIC Did Not Predict Failure of Debridement, Antibiotics, and Implant Retention (DAIR) for Total Hip and Knee Arthroplasty Acute Postoperative Periprosthetic Joint Infection
Brian Chalmers, Milan Kapadia, Yu-fen Chiu, Andy Miller, Michael Henry, Alberto Carli

55: Results of Irrigation and Debridement for PJI with the Use of Intraosseous Antibiotics
Beau Kildow, Shaun Patel , Jesse Otero, Keith Fehring, Brian Curtin, Bryan Springer, Thomas Fehring

58: Deep infection after distal radius open-reduction internal fixation.
Tyler Henry, Richard McEntee, Jonas Matzon, Pedro Beredjiklian, Kevin Lutsky

59: Infection Rates Associated with Immediate Use Steam Sterilization
Alex Demers, Thomas Moran, Victor Anciano, Joseph Park

60: Does performing total joint arthroplasty in the afternoon or evening increase the risk of prosthetic joint infection?
Ibrahim Tuncay, Orkhan Aliyev

64: Antibiotic Stewardship Interventions Significantly Improve Preferred Antibiotic Prophylaxis in Elective Primary Total Joint Arthroplasty
Raquel Roberts, Katelyn Quartuccio, Jessica Stern, Eric Heintz, Kelly Pillinger, Thomas Myers

66: KLIC and CRIME80 Do Not Predict DAIR Success for PJI
Christine Wu, Sean Ryan, Zoe Hinton, William Jiranek, Jessica Seidelman, Thorsten Seyler

67: ED Utilization in TJA: Analysis of PICC Readmissions
Zoe Hinton, Sean Ryan, Christine Wu, Jessica Seidelman, William Jiranek, Thorsten Seyler

69: Decreased 90-Day Surgical Site Complication Rates with Closed Incision Negative Pressure Therapy after Revision Knee Arthroplasty: A Randomized Trial
Ahmed Emara, Herbert Cooper, Michael Cross, George Guild, Denis Nam, Michael Nett, Giles Scuderi, Fred Cushner, Ronald Silverman, Carlos Higuera Rueda

70: High Rate of Infection Associated with Arthroscopic Lysis of Adhesions for Arthrofibrosis following Total Knee Arthroplasty
Nathan Thomas, Christina Liu, Nathan Varady, Pierre-Emmanuel Schwab, Yhan Colon Iban, Antonia Chen

71: Lower Socioeconomic Status is Associated with Increased Risk of Girdlestone Resection Arthroplasty Following Periprosthetic Infection of the Hip
Gregory Kirchner, Alexander Lieber, Yehuda Kerbel, Raymond Kim, Vincent Moretti, Lucas Nikkel

75: Surprising Little Impact of Obesity on Outcomes Following 2 Stage Reimplantation Total Knee Arthroplasty for Infection
Yehuda Kerbel, Joseph Koressel, Brian Perez, Ryan DeAngelis, Gwo-Chin Lee

76: Increasing Complications and Failures with Increasing BMI in Patients Undergoing 2-Stage Exchange for Infected THA
Yehuda Kerbel, Nicolas Pascual-Leone, Ariana Meltzer-Bruhn, Matthew Stein, Gregory Kirchner, Gwo-Chin Lee

80: ASA after total hip and knee arthroplasty can significantly reduce post operative persistent wound drainage
Alisina Shahi, Alec Kellish, Vishavpreet Singh, Ali Oliashirazi

84: Plasma D-Dimer Does Not Determine the Fate of Reimplantation in Two-Stage Exchange Arthroplasty
Tejbir Pannu, Jesus Villa, Charles Engh III, Brett Levine, Jorge Manrique, Nicolas Piuzzi, Aldo Riesgo, Carlos Higuera Rueda

85: Impact of joint type on time to aspiration and targeted antibiotic administration in patients with septic arthritis
Edward Woods III, Anne Sullivan

86: Outcomes of Knee Endofusion for Prosthetic Joint Infection
Alexandra Stavrakis, Sai Devana, Madhav Chowdhry, Edward McPherson, Matthew Dipane

87: Outcomes of Patients Undergoing Second Stage Reimplantation following Knee Endofusion for PJI
Alexandra Stavrakis, Sai Devana, Madhav Chowdhry, Edward McPherson, Matthew Dipane

89: Compressive Osseointegration Device for Management of Previously Infected, Non-Oncologic Salvage Arthroplasty
Scott Galey, James Chen, Shannon Wu, Mahdav Chowdhry, Matthew Dipane, Nicholas Bernthal, Adam Sassoon, Edward Mcpherson

99: A dry aspiration prior to reimplantation arthroplasty should not be considered reassuring
Joseph Karam, Steven Yacovelli, Matthew Grosso, Javad Parvizi

105: Risk Factors Associated With Developing Surgical Site Infections or Peri-Prosthetic Joint Infections Following Primary Total Hip Arthroplasty for Acetabular Fractures
Rushabh Vakharia, Matthew Ciminero, Angelo Mannino, Asad Ashraf, Michael Mont, Kevin Kang

106: Transverse Posterior Wall Acetabular Fractures Undergoing Conversion Total Hip Arthroplasty are at High-Risk of Periprosthetic Joint Infection
Kyle Cichos, Clay Spitler, Gerald McGwin Jr, Molly Fleece, Elie Ghanem

1:50pm-2:15pm Central Time

Closing remarks, New President Introduction
Carlos Higuera Rueda, MD
Angela Hewlett, MD

30th Annual Open Scientific Virtual Meeting
August 7-8, 2020
Poster Presentations

Poster presentations will be available to view at anytime
August 1, 2020-August 8, 2020
Poster presentions will NOT be included in the “Questions and Answers” Sessions.

MSIS appreciates Support from our Exhibitors